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Analysis of nicotinic AChR(nAChR) using (123)I-5-Iodo-3-[2(S)-2-azetidinylmethoxy]pyridine (5IA-85380)-SPECT indicates decreased uptakein the frontal, temporal, and cingulate cortex, as well asthe striatum in DLB patients, compared to healthy con-trols (O’Brien et al., 2008); in contrast, the study showeddecreased uptake in medial temporal lobe, frontal cortex,striatum, and pons, respectively, in AD patients (O’Brienet al., 2007). (2003) Imaging the pathology ofAlzheimer’s disease: amyloid-imaging with positron emissiontomography.

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